There is a sentence that is missing in the paragraph below. Look at the paragraph and decide where (option 1, 2, 3, or 4) the following sentence would best fit.
Paragraph: The nations of the Silk Roads are sometimes called 'developing countries', but they are actually some of the world's most highly developed countries, the very crossroads of civilization, in advanced states of disrepair ___ (1) ___ . These countries lie at the centre of global affairs: they have since the beginning of history. Running across the spine of Asia, they form a web of connections fanning out in every direction, routes along which pilgrims and warriors, nomads and merchants have travelled, goods and produce have been bought and sold, and ideas exchanged, adapted and refined ___ (2) ___ . They have carried not only prosperity, but also death and violence, disease and disaster ___ (3) ___ . The Silk Roads are the world's central nervous system, connecting otherwise far-flung peoples and places ___ (4) ___ . It allows us to see patterns and links, causes and effects that remain invisible if one looks only at Europe, or North America.
Sentence: Understanding central Asia's role helps developments make more sense not only across Asia but in Europe, the Americas and Africa.